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While macular degeneration generally is associated with aging eyes, an inherited form known as Stargardt's disease can affect children and young adults.
Stargardt's disease — also called fundus flavimaculatus or Stargardt's macular dystrophy SMD — affects approximately one in 10, people and is characterized by central vision loss early in life.
Some researchers believe a distinction should be made between Stargardt's disease and fundus flavimaculatus, because they say each describes a different variant of the eye disease.
Stargardt's generally refers to a group of inherited diseases causing light-sensitive cells in the inner back of the eye retina to deteriorate, particularly in the area of the macula where fine focusing occurs.
Central vision loss also occurs, while peripheral vision usually is retained. Stargardt's disease is diagnosed by the presence of small, yellowish spots of deteriorating tissue drusen sloughed off from the colored or outer covering of the retina retinal pigment epithelium.
Progressive vision loss eventually leads to blindness in most cases. Stargardt's is an inherited disease passed along to children when both parents carry mutations of a gene associated with vitamin A processing in the eye.
Parents can carry recessive genetic traits responsible for Stargardt's, even though they themselves may not have the disease.
Researchers have found that about 5 percent of people carry gene mutations that cause inherited retinal diseases such as Stargardt's disease and retinitis pigmentosa.
However, the inheritance pattern of Stargardt's is variable, and it's possible for up to half of the children of a single affected parent to develop the condition.
Also, you can't predict how much vision a child may lose to Stargardt's disease based on the affected parent's vision loss.
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Essential cookies We use essential cookies to perform essential website functions, e. Tapping left the show for season five to concentrate on Sanctuary , and was replaced by Robert Picardo , who reprised his role as Richard Woolsey from both SG-1 and Atlantis.
However, in late summer it was announced that SciFi would not renew Atlantis. The final episode aired on January 9, Stargate Universe is the third live-action Stargate series, and premiered on October 2, The series was pitched to the Sci Fi Channel in the fall of , just before the writer's strike—which put a hold on the project.
Syfy announced on December 16, that they would not pick the show up for a third season. After the events of Stargate Atlantis , research into the Stargate's 9th and final chevron  leads to an expedition being stranded several billion light years from earth on board an Ancient ship called Destiny which has been traveling through the universe unmanned for millions of years.
The show follows the crew as they struggle to survive on board Destiny with no apparent way home. The show was intended to have a darker tone than its predecessors and delve more into the humanity of the characters and their relationships with each other.
The film is the conclusion of Stargate SG-1 's Ori arc, and picks up after the SG-1 series finale, but takes place before the fourth season of Stargate Atlantis.
Some scenes for this movie were already shot at the end of March , but the original start date was set for May 22 at Vancouver's Bridge Studios. A few months before its release, executive producer Brad Wright announced it was to have with brand new visual effects and scenes not previously included in the television version.
The beginning was to be slightly altered, a new scene added, and the nudity scene taken out to make this episode suitable for children, with the final movie roughly seven minutes shorter than the original episode.
According to Sci-Fi and Joseph Mallozzi , a Stargate Atlantis two-hour direct-to-DVD movie was given the go ahead after the series was cancelled at the end of its fifth season.
More movies were expected to follow in the Atlantis series if the first movie was successful. By May the script for the film was finished.
He also confirmed that the proposed Stargate SG-1 and Atlantis movies have been permanently shelved, along with another movie idea he had been trying to get a greenlight on that would have involved cast members of all three series.
Still, Wright did not rule out future Stargate films, saying; "It's a franchise. Stargate is not over. Somebody smart from MGM is going to figure it out, and something will happen.
In May , MGM announced a re-imagined version of the original film to be produced as a trilogy with Warner Bros. Emmerich will direct and Devlin will produce.
This set of two sequel films to the original Stargate starring Kurt Russell and James Spader will take a dramatically different course than the SG-1 and Atlantis universe created in the following 15 years.
It focuses on the character of Catherine Langford and is a prequel to both the television continuity and the original feature film.
The shooting began in August and series premiered online at the Stargate Command website on February 14, Stargate Infinity is an American animated science fiction television series created by Eric Lewald and Michael Maliani as a spin-off from its sister show , Stargate SG The story arc in Infinity is set 30 years into the future and follows Gus Bonner and his team.
Bonner's team was created after he was framed for a crime he did not commit. Together with his team he escapes through the Stargate with the chrysalis.
From that point forward they go from planet to planet until they find the evidence to clear their names while learning about the unique cultures in the galaxy , so that they can one day return to Earth.
Due to its lack of popularity the show is almost completely unrecognized. The series was cancelled before any of its story arcs could be resolved.
The show was of low budget , which was constantly noted by the media. Factory , a company known for releasing cult animated series, acquired the rights to the show and released the entire series to DVD on May 13, in Region 1.
The writers and producers of Stargate SG-1 , Stargate Atlantis and Stargate Universe and the main canon of the Stargate franchise were not involved with Infinity , and neither MGM, the production teams nor the fans of Stargate consider Infinity to be an official part of the Stargate universe.
According to Stargate SG-1 co-creator Brad Wright , the animated series should not be considered official Stargate canon. Commenting on it, he stated, "I don't have a problem with it.
I'm just not involved. Cooper told the fansite GateWorld exclusively that he was working to continue SG However, SciFi has attempted to block other networks from taking up the show, citing its original exclusive contract with MGM.
In , Omar Zuhdi, a Shawnee high school teacher, was able to get a court date to proceed in a trial against the makers and originators of the original movie, claiming that they stole the plot and story of his film script Egyptscape , as the basis of the film Stargate.
There are three series of novels based on the Stargate franchise, one based on the original Stargate film and two based in the Stargate SG-1 and Stargate Atlantis television shows.
A series of books written by Bill McCay were published from to that were unofficial sequels to the film. Neither party has commented on whether McCay's interpretation was correct.
Despite attempting to remain close to the original vision, the subsequent television series Stargate SG-1 which began under an entirely independent development developed the story along different lines, making no attempt to reconcile the plot lines of the books.
This marked the first major branching of the franchise. Fandemonium books became available in the US in The official Stargate Magazine , produced by Titan Publishing, began publishing short stories written by Fandemonium authors in their 8th issue.
The stories alternate between both SG-1 and Atlantis. Five have been published to date, with stories by James Anthony and artwork by Jorge Correa.
From Wikipedia, the free encyclopedia. American adventure military science fiction franchise. For the film, see Stargate film.
For the device itself, see Stargate device. For other uses, see Stargate disambiguation. Main article: List of Stargate games.
Main article: Stargate film. Main article: Stargate SG Main article: Stargate Atlantis. Casino All 27 Roulette All 8 3. Blackjack All 4 4.
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Top bonuses! Enjoy loads of bonuses and promotions. Over the past several decades, researchers have identified hundreds of genes that contribute to inherited eye diseases, including Stargardt disease.
Many studies continue to explore the biology and genetics of Stargardt disease, and of macular degeneration more generally.
The main goals are to better understand the natural course of the disease, to make contact with people who may be interested in future clinical trials, and to collect blood, skin, and DNA samples from those people.
Such mechanistic studies can lead to new treatment strategies. One strategy currently under study is to reduce the build-up of lipofuscin and other toxic byproducts in the retina.
In mice and larger animal models, an oral form of ALK slows the formation of lipofuscin deposits. They found that some FDA-approved drugs can reduce retinal damage in the mice.
Gene replacement therapy requires a method for delivering the gene of interest into cells, and for some diseases, the solution has been to package the gene inside a small, harmless virus called the adeno-associated virus AAV.
Tests in the Stargardt mouse model showed that this approach can reduce lipofuscin accumulation. Oxford Biomedica has refined this technology, and licensed it under the name StarGen.
Finally, stem cell-based therapies are showing promise for Stargardt disease in clinical trials. Stem cells are immature cells that can generate many mature cells types in the body, including the photoreceptors that die off in Stargardt disease.
Human stem cells can be derived from embryonic or adult tissues. These cells provide support and nourishment to the retina.
Other clinical and laboratory studies are making use of adult cells that have been reprogrammed into stem cells, called induced pluripotent — or iPS — cells.Also consistent with the same story are a variety Butterflykyodai booksvideo games and comic booksas well as the direct-to-DVD movies Stargate: Children of the Gute Playstore SpieleStargate: The Ark of Truthand Stargate: Continuumwhich concluded the first television show after 10 seasons. Alkeus Pharmaceuticals. If you have Stargardt's, your eye doctor also may suggest that you wear eyeglasses with Bet90 Ltd Starga lenses to block Englische Spitznamen wavelengths of light. These photos may reveal the presence Kostenlos Spielen 3 Gewinnt Ohne Anmeldung lipofuscin deposits. Archived from the original on December 17, Retrieved April 27, June Saturn Awards. Accessed March Those who have the fundus flavimaculatus form of the disease, Spiel 2021, are likely to experience even more severe vision loss.